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Compounded Semaglutide

Important Notice:

Compounded semaglutide has not been approved by the FDA, and the FDA does not assess the safety or efficacy of compounded medications.

This document provides an overview of compounded semaglutide, including guidance on its safe and effective use for weight loss. Upon receiving your prescription, you will also find a printed medication guide or patient drug information in your package. It is essential to read all the provided details regarding your prescribed medication before use. If you are uncertain about your prescription, please refer to the label on your medication bottle(s) or reach out to us for clarification.

Key Safety Information About Compounded Semaglutide

Serious Risks and Warnings:

  • Potential Thyroid Tumors or Cancer: Inform your healthcare provider if you notice swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath, as these may indicate thyroid cancer. In rodent studies, semaglutide and similar medications have been linked to thyroid tumors and cancer. However, it is unknown whether these findings apply to humans.

  • Do Not Use If: You or your family have a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

  • Pregnancy Precautions: Women of reproductive potential should stop using compounded semaglutide at least two months before a planned pregnancy due to its long half-life.

  • Emerging Research on Eye Health: A recent study suggests a possible association between semaglutide and a vision-threatening condition called non-arteritic anterior ischemic optic neuropathy (NAION). While data is limited, patients should be informed of this potential risk and consult their provider if concerned.

What is Compounded Semaglutide?

Compounded semaglutide is an injectable prescription medication that may aid individuals with obesity or excess weight (overweight) who have weight-related health concerns in achieving and maintaining weight loss.

  • It should be used in combination with a reduced-calorie diet and increased physical activity.

  • It should not be taken with other medications containing semaglutide or any GLP-1 receptor agonist.

  • The safety of compounded semaglutide in individuals with pancreatitis, gastroparesis, or in children under 12 years old is unknown.

Medication Overview

This document covers the following:

  • Usage Guidelines

  • Maximizing Treatment Benefits

  • Warnings & Safety Information

  • Potential Side Effects

  • Missed Doses & Storage

How to Use Compounded Semaglutide

1. Administration Instructions:

  • Follow the provided Instructions for Use and your provider’s dosage schedule.

  • Treatment begins with a gradual dose increase over 3-4 months. Your provider will determine the appropriate schedule.

  • Each syringe contains 100 units, and dosing is adjusted accordingly.

  • Inject subcutaneously into the abdomen, thigh, or upper arm—not into a muscle or vein.

  • Rotate injection sites each time, keeping at least an inch apart within the same body area.

  • Take compounded semaglutide once a week, on the same day each week, with or without food.

2. Missed Dose Guidelines:

  • If your next scheduled dose is within 48 hours, skip the missed dose and continue as usual.

  • If more than 48 hours remain, administer the missed dose as soon as possible and resume the normal schedule.

  • If two or more doses are missed, contact your care team for guidance on resuming treatment.

3. Surgery Precautions:

  • If you are undergoing surgery with general anesthesia, the American Society of Anesthesiologists (ASA) recommends stopping semaglutide at least one week before to reduce risks.

  • You may restart the medication upon receiving clearance from your surgeon. If it has been more than two weeks since your last dose, consult your provider before resuming.

Storage Guidelines

  • Keep refrigerated at 36°F to 46°F (2°C to 8°C) until use.

  • Store in the original carton to protect from light.

  • Do not freeze or use if frozen or exposed to temperatures above 86°F.

  • Once punctured, a vial should be used within 28 days.

  • Dispose of any remaining medication after 28 days and start a new vial.

Alcohol & Semaglutide

While moderate alcohol consumption is not strictly prohibited, excessive alcohol intake may increase the risk of low blood sugar, nausea, or dizziness. Avoid driving or operating heavy machinery after consuming alcohol.

Potential Side Effects

Like all medications, compounded semaglutide may cause side effects. Some are mild and temporary, while others may be more serious. If you experience severe or persistent side effects, contact your healthcare provider immediately.

Common Side Effects:

  • Nausea, vomiting, or diarrhea

  • Constipation

  • Stomach pain or bloating

  • Fatigue

  • Headache

  • Decreased appetite

Serious Side Effects (Seek Medical Attention if Occurs):

  • Severe abdominal pain (may indicate pancreatitis)

  • Persistent nausea or vomiting leading to dehydration

  • Rapid heartbeat or palpitations

  • Vision changes or sudden loss of vision

  • Severe allergic reaction (swelling of face, tongue, or throat, difficulty breathing)

  • Signs of low blood sugar (dizziness, sweating, confusion, shakiness)

If you experience any concerning symptoms, stop using the medication and consult your provider immediately.

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